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Health care professionals and consumers are encouraged to report serious adverse events (side effects) or product quality problems with the use of these products to the FDA’s MedWatch Adverse Event Reporting program online, by regular mail, fax or phone.
Dioscorides’ De Materia Medica is often said to be the oldest and most valuable work in the history of pharmacology.[2] The origins of clinical pharmacology date back to the Middle Ages in Avicenna’s The Canon of Medicine, Peter of Spain’s Commentary on Isaac, and John of St Amand’s Commentary on the Antedotary of Nicholas.[3] Clinical pharmacology owes much of its foundation to the work of William Withering.[4]
well as a peculiar acid � meconic acid. The alkaloids are chiefly combined with meconic acid or sulphuric acid, but may be partly free. The three most important alkaloids are morphine, codeine, and thebaine. The others are papaverine, pseudomorphine or oxymorphine, gnoscopine, codamine, laudanine, laudanosine, meconidine, lanthopine, protopine, cryptopine, narcotine, oxy-
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